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Suggestions within category "Heart and Vascular"

Advanced Heart Failure and Transplant Angina Arrhythmias Cardiac Rehabilitation Coronary Artery Disease Heart Structure Defect/Congenital Heart Defect Heart Valve Research Hypertension LVAD Peripheral Artery Disease Preventative Cardiology Pulmonary Embolism
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Global SYMPLICITY Registry (GSR) Denervation Findings in Real World (DEFINE)- US Cohort is referred to as the GSR DEFINE- US Cohort study

A PROSPECTIVE, OBSERVATIONAL STUDY THAT WILL DOCUMENT THE LONG-TERM SAFETY, EFFECTIVENESS, AND DURABILITY OF RENAL DENERVATION IN A REAL-WORLD POPULATION, AGED 65 YEARS OR GREATER WITH HYPERTENSION IN THE UNITED STATES.

Contact(s):

Sarah Ackroyd - sackroy1@hfhs.org

Principal Investigator: Herbert Aronow
Principal Investigator ID: haronow1@hfhs.org
Sex: Male or Female
Age: 18 years and over
Phase: N/A
Healthy Volunteers:
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
STUDY PARTICIPANTS ARE >65 YEARS, WITH DIAGNOSED HYPERTENSION AS SEEN AND EVALUATED BY CARDIOVASCULAR INTERVENTIONALIST.
Exclusion Criteria:
THERE IS NO EXCLUSION CRITERIA IN THIS OBSERVATIONAL STUDY.
Interventions: Drug/Device: SYMPLICITY SPYRAL CATHETER
Conditions: HYPERTENSION, ISOLATED SYSTOLIC HYPERTENSION, COMBINED HYPERTENSION
Keywords: COMBINED HYPERTENSION, HYPERTENSION, ISOLATED SYSTOLIC HYPERTENSION

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HEART Camp Connect - R01

This study aims to promote long-term adherence to exercise in adults with heart failure with preserved ejection fraction (HFpEF) by providing an exercise coach for up to one year. We will test a virtual group and in-person group against each other and against virtual enhanced usual care.

Contact(s):

Crystal Grimshaw - cgrimsh1@hfhs.org

Principal Investigator: Steven Keteyian
Principal Investigator ID: sketeyi1@hfhs.org
Sex: Male or Female
Age: 18 years and over
Phase: N/A
Healthy Volunteers:
This study is NOT accepting healthy volunteers
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Inclusion Criteria:

• diagnosis heart failure with EF >50%
• age >19 years old
• Echocardiogram within past 24 months
Exclusion Criteria:

• chest pain
• heart attack, coronary artery bypass surgery, or pacemaker implant within past 6 weeks
• ICD (defibrillator)
Interventions: Drug/Device: NA
Conditions: HFpEF
Keywords: exercise, heart failure, heart failure with preserved ejection fraction, HFpEF

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The Fourth Left Atrial Appendage Occlusion Study: (LAAOS-4)

The purpose of the LAAOS-4 study is to determine if closure of the left atrial appendage using a closure device called the WATCHMAN?, in addition to taking oral anticoagulant medications, is more effective at reducing strokes and blood clots in your body, than taking oral anticoagulant medications on their own.

Contact(s):

Briita Wanhala - bwanhal1@hfhs.org

Principal Investigator: Waddah Maskoun
Principal Investigator ID: wmaskou1@hfhs.org
Sex: Male or Female
Age: 18 years and over
Phase: N/A
Healthy Volunteers:
This study is NOT accepting healthy volunteers
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Inclusion Criteria:

• Adults, 18 years or older
• Have long-term atrial fibrillation (persistent or permanent) OR paroxysmal atrial fibrillation with a history of stroke or blood clots
• Taking an oral anticoagulant
Exclusion Criteria:

• Unable to tolerate oral anticoagulants
• Prior closure of the left atrial appendage
Interventions: Drug/Device: WATCHMAN device
Conditions: Atrial Fibrillation
Keywords: Atrial Fibrillation, oral anticoagulation, WATCHMAN

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A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing Olpasiran Use to Prevent First Major Cardiovascular Events in Participants with Elevated Lipoprotein(a)

This research study is testing whether an investigational medication called olpasiran can help prevent serious heart and blood vessel problems, such as a heart attack or stroke, in people who have high levels of a substance in their blood called lipoprotein(a), or Lp(a), and who are at increased risk of having a cardiac event.

Contact(s):

Jodi Carter - GeneralCardiologyResearch@hfhs.org

Principal Investigator: Sachin Parikh
Principal Investigator ID: sparikh2@hfhs.org
Sex: Male or Female
Age: 18 years and over
Phase: III
Healthy Volunteers:
This study is NOT accepting healthy volunteers
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Inclusion Criteria:

• Age 50 or greater
• Lp(a) greater than or equal to 200 nmol/L
Exclusion Criteria:

• Prior arterial revascularization
• Severe kidney dysfunction
• Severe liver dysfunction
Interventions: Drug/Device: Olpasiran (AMG 890)
Conditions: Elevated Lipoprotein(a), at risk for first cardiovascular event
Keywords: atherosclerosis, CAD, Elevated Lipoprotein(a), Lp(a)

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A Phase 3, Randomized, Multicenter, Double-Blind, PlaceboControlled Study of Acoramidis for Transthyretin Amyloidosis Prevention in the Young (ACT-EARLY Trial)

ACT-EARLY is a research study to see if an investigational drug, acoramidis (AG10), is safe and effective in preventing or delaying symptoms of a disease called Transthyretin Amyloidosis (ATTR).This research study will test whether acoramidis treatment in people who do not have the disease but who carry a genetic predisposition to developing the disease is safe and effective in preventing or delaying ATTR disease (genetic predisposition is also referred to as genetic variant).

Contact(s):

Kristin Clark - kclark2@hfhs.org

Principal Investigator: Celeste Williams
Principal Investigator ID: cwillia6@hfhs.org
Sex: Male or Female
Age: 18 years and over
Phase: III
Healthy Volunteers:
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Carries a specific change (mutation) in the TTR gene that is known, or strongly believed, to cause disease. However, they currently have no signs or symptoms of that disease. The participant's age must be close to the age when people with their specific TTR gene variant typically start developing symptoms. Specifically, they must be no more than 10 years younger than that expected age. They can be older than the expected age, as long as they are 75 years old or younger.
Exclusion Criteria:
No current stymptoms caused by ATTR amyloidosis. No current tratment for ATTR amyloidosis
Interventions: Drug/Device: Acoramidis
Conditions: Transthyretin Amyloidosis (ATTR)
Keywords: Acoramidis, Amyloidosis, ATTR Cardiomyopathy (ATTR-CM), ATTR Polyneuropathy (ATTR-PN), Transthyretin Amyloidosis (ATTR)

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